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CYP17 adı maruz bir genin varyasyonu, cinsiyet hormonlarının metobalizmasında gösteriş oynamaktadır ve er dimağ gelişimini etkilemektedir. Bu varyasyon erkeklerde hanımlara nazaran daha yaygındır. 2008’de Avusturya’da meydana getirilen bir çatlakştırmada, Clemens Tempfer ve meslektaşları kadından erkeğe transseksüellerin %44